We demonstrated that Zfp238 inhibits Foxo1 transcriptional activity and that adipose-tissue-specific Zfp238 knockout mice (Adipo-Zfp238KO) show obesity, decreased whole-body O2 consumption, and decreased expression of Ucp1 stimulated with cold exposure or β3 agonist in subcutaneous adipose tissue. Here, FOXO1 is linked to Obesity.