This analysis resulted in the identification of a number of cellular proteins that changed as a result of latent infection of monocytes and included S100A8 and A9 (detected with 14 and 11 unique peptides, respectively), which were two of the most robustly downregulated proteins during latent infection (Figure 4C). This evidence concerns the gene IGKV1D-22 and disease arising from reactivation of latent virus.