However, although we do not rule out that such latency-associated changes during latent infection could affect, e.g., CD4+ and CD8+ T cell effector functions in the periphery, we think it likely that such latency-associated changes could aid T cell evasion in, e.g., the microenvironment around latently infected cells in tissues such as bone marrow. Here, CD4 is linked to disease arising from reactivation of latent virus.