Tim‐3 is an important member of the Tims family which is expressed explicitly in CD4+ Th1 cells and other related immune cells except Th2 cells.9 In addition, Tim‐3 is expressed in tissues and organs which are involved in innate immune, and specific immune response and is closely related to the progression and outcome of various diseases.9, 10 Tim‐3 is mainly expressed in microglia in the brain and involved in the inflammatory response in CNS diseases, including ischemic stroke, multiple sclerosis, and cerebral parasitic disease.10, 11. This evidence concerns the gene HAVCR2 and ischemic stroke.