Highly up‐regulated in liver cancer (HULC), originally found in hepatocellular carcinoma and served as an oncogene, has been found dysregulated in various human tumours, such as osteosarcoma, colorectal carcinoma, gastric cancer and diffuse large B‐cell lymphoma.14, 34, 35, 36 Although the importance of HULC in regulating cell proliferation, migration and invasion has been demonstrated, the mechanisms underlying HULC overexpression in cancer cells remain unclear. This evidence concerns the gene HULC and osteosarcoma.