GP73 is a highly phosphorylated protein located in the Golgi apparatus that can also be cleaved and secreted into serum.7, 8 GP73 is highly expressed in several kinds of cancers, including HCC, nonsmall cell lung cancer, breast carcinoma, pancreatic carcinoma, melanoma, and prostate carcinoma.9, 10, 11, 12, 13 As the expression of GP73 was positively associated with the process of cancers, this protein has been regarded as a novel serum biomarker in the diagnosis of cancers, especially in HCC diagnosis.9, 14, 15. This evidence concerns the gene GOLM1 and cancer.