In addition, it was shown that ERK1/2 signalling is limited to non‐myocyte compartment of MFS mouse heart and upon pressure overload, it contributes to cardiomyopathy, emphasizing ERK signalling to be a crucial therapeutic target in MFS.26 Here, we speculate that the induced Igfbp2 levels in mgR/mgR mice could be crucial in regulating pERK1/2 levels in MFS and this needs further investigation. This evidence concerns the gene MAPK3 and cardiomyopathy.