FBN1 and Marfan syndrome: It is known that calcium influx regulates FBN1 expression.55 Moreover, calcium channel blockers, are used as a second line of therapy in 10%‐20% MFS patients who are intolerant to β‐blockers.56 However, calcium channel blockers have detrimental effects in MFS mice and are associated with an increased risk of cardiovascular pathology in human MFS.57 All these data, highlight the importance of our finding on calcium signalling and its implication in MFS management.