AGTR1 and aortic aneurysm: Several studies have shown that there is an increased abundance of TGF‐beta in MFS.8, 10 In addition, non‐canonical TGF‐beta signalling pathway (extracellular signal‐regulated kinase [ERK] 1 and 2) has also been shown to promote aortic aneurysms in Marfan mice.11 TGF‐beta neutralizing antibodies (1D11) and Losartan (an angiotensin II type 1 receptor [AT1] antagonist) have been shown to decrease TGF‐beta signalling in Marfan mouse models.