IL6 and aneurysm: Ccl8 was also shown to be induced during AAA in mice.21 The role of IL6‐STAT3 signalling in contributing to aneurysm dilation has been shown in mgR/mgR Marfan model.35 In MFS patients, inflammation correlated with aortic disease, emphasizing the crucial role of inflammatory signalling in aortic disease progression.33 It is known that defective fibrillin‐1 in MFS leads to impaired collagen and network organization.