SPP1 and aneurysm: We selected and validated the genes randomly (Lrrc17, Gxylt2, Mfsd2a, Scube and Ank2) and based on their role in aneurysms (Mmp12, Spp1, Ctss) or cardiovascular complications (Mfap4, Igfbp2) or inflammatory signalling pathways (Ccls and Ccrs).