IGFBP2 and cancer: There have been conflicting reports about the role of Igfbp2 in cancers, as there is evidence supporting it to be both a tumour suppressor and an oncogene in different cancers.24 In glioma cells, Igfbp2 promotes pERK1/2 phosphorylation via integrin β1, thus regulating cell proliferation and invasion.25 It is known that pERK1/2 levels are induced in MFS mice and it has been proposed that abolishing pERK1/2 levels could be a potential therapy towards MFS.11, 20