CCL8 and triple-A syndrome: T cells (CD8+ and CD4+) have been shown in adventitia of MFS aortas, emphasizing a crucial role of immune cells in both medial and adventitial layers of MFS aorta.33 Previously, studies have reported inflammatory genes to be involved in both mouse and human AAA.15, 21, 34 Among the chemokines identified in our data, Ccl8 was highly up‐regulated at both RNA (in RNA‐ sequencing, qPCRs datasets) and protein levels.