Previous study reported that O‐GlcNAc modification of ribosomal subunits contributed to the translational machinery.12 Of numerous eukaryotic initiation factors in translational machinery, eIF4E is a key player in the regulation of translation initiation and is required for the recruitment of specific mRNAs to the ribosome.30 eIF4E has been reported to regulate the self‐renewal of glioma‐initiating cell.31 These findings promoted us to investigate whether eIF4E was O‐GlcNAcylated. Here, EIF4E is linked to central nervous system cancer.