Although the transferred CD4+ memory T cells had no effect on infectious viral burden in the serum, brain, or testes on day 3 post-infection in the high dose-infected mice (Fig 4A), we observed a significant reduction in viral burden in some tissues (e.g., spleen, sciatic nerve, and female reproductive tract [FRT]) of mice injected with memory CD4+ T cells and inoculated with a low dose of ZIKV (Fig 4B). The gene discussed is CD4; the disease is infection.