INS and type 1 diabetes mellitus: Another group investigated the role of AM80 in type 1 diabetes in mice [21] and found that one of the AM80 doses used in their study, 1 mg/Kg for 19 days, reduced hyperglycemia and insulitis, a typical type 1 diabetes consequence in which there is a profuse infiltration of T lymphocytes into the pancreas insulin-secreting β-cells, with progressive destruction of the insulin-producing cells.