CDH1 and prostate intraepithelial neoplasia: Most of the atypical cells within PIN lesions from both p16L/L:PB-Cre4 and R26hARL/wt:p16L/L: PB-Cre4 mice showed positive staining for E-cadherin (Fig 2C5 and Fig 2D5) and cytokeratin-8, CK8, (Fig 2C6 and Fig 2D6), which was consistent with their luminal epithelial origin.