Again we found a highly significant increase of total c-fos in fearful situation in Wt, as well as in 5-HT1A(-/-) mice (Wt naïve 11.64±0.45, 1A-ko naïve 32.74±1.45, p≤0.001, Wt anxiety 179.9±4.6, 1A-ko anxiety 211.33±5.36, p≤0.001). This evidence concerns the gene FOS and Anxiety.