Beyond their common negative effects on scavenger receptor SR-AI and MARCO expression, both NTHI and SP each mediated additional and distinct reductions in bacterial recognition receptor expression in subjects with COPD; NTHI significantly reduced expression of complement and adhesion receptor CD11b in both COPD-ES and COPD-S, and complement receptor CD35, mannose pattern recognition receptor CD206 only in COPD-ES. Here, ITGAM is linked to chronic obstructive pulmonary disease.