A statistically significant linear concentration-response effect (inverse) was observed only for FP inhibition of NTHI-stimulated release of IL-1β in MDMs from COPD-ES and COPD-S, and NTHI-stimulated release of IL-8 in MDMs from COPD-ES, with the greatest suppression at 10 nM)(Fig 5). This evidence concerns the gene CXCL8 and chronic obstructive pulmonary disease.