When we evaluated the effect of tobacco smoke on changes in receptor expression induced by NTHI or SP on COPD-S and Sm MDMs, Sm had a greater number of receptors that were significantly reduced by NTHI (all measured receptors except CD16) as compared to COPD-S (SR-AI and CD11b only) (Table 2). The gene discussed is ITGAM; the disease is chronic obstructive pulmonary disease.