BAI, the major flavonoid glycoside responsible for the biological activity of S. baicalensis, has been hypothesized to possess neuroprotective effects.30 A previous study reported that BAI effectively improved memory deficits and reduced AD‐like pathological changes in Aβ‐injected ICR mice.31 Compared to an AD rat model, APP/PS1 mice, which overexpress the Swedish mutation of APP and contain a deletion of exon 9 in PS1, are more reliable and easily operable, and they serve as a powerful model for AD research. The gene discussed is APP; the disease is Alzheimer disease.