Microglial activation induced by Aβ deposition and the release of overwhelming levels of proinflammatory cytokines causes neuronal apoptosis in AD.25, 26 To observe whether BAI could attenuate neuronal apoptosis in APP/PS1 mice, we used immunohistochemical and Western blot assays to detect the expression of Cleaved‐CASP3 in the hippocampus. The gene discussed is CASP3; the disease is Alzheimer disease.