IL18 and Alzheimer disease: Activated microglia, characterized by branching processes and an enlarged cell shape, produce a wide spectrum of proinflammatory cytokines, such as IL‐1β, iNOS, IL‐18, and other mediators, which ultimately induce neuronal damage in the AD‐affected brain.37 Therefore, the inhibition of microglial activation is a key goal for the treatment of AD.