There was no labeling with NCC, pendrin, or NHE‐3 antibodies in renal cysts, indicating the lack of B‐intercalated cells, principal cells, distal convoluted tubule cells, proximal tubule cells or thick ascending limb of Henle cells in cyst epithelium adult Ren1cCreTsc1 mice. Here, SLC12A3 is linked to Renal cyst.