To build on these initial studies of Tsc‐associated renal cystic disease in the mouse model system, we employed two newly developed mouse Tsc‐renal cystic disease models, one that disrupts the Tsc2 gene in renal principal cells, and the other that disrupts the Tsc1 gene in renal pericytes. This evidence concerns the gene SLC12A3 and cystic kidney disease.