Despite these limitations, our findings demonstrate that AMEs lacking mutations affecting HRAS, PIK3CA and AKT1 may harbor the HMGA2-WIF1 fusion gene, previously described in salivary gland PAs and carcinomas ex-PA,10,16 suggesting that a subset of AMEs may be genetically related to PAs or that AMEs may originate in the context of breast PAs. This evidence concerns the gene HRAS and gonorrhea.