IL2 and Atherosclerotic lesion: In a renal ischemia–reperfusion injury (IRI) mouse model, IL-2 IC reduced expression of inflammatory cytokines and attenuated the infiltration of neutrophils and macrophages in renal tissue.69 IL-2 IC treatment has also been studied in experimental renal cancer.69 In experimental atherosclerosis, IL-2 IC in combination with anti-CD3 antibody markedly reduced atherosclerosis lesions.70 This effect was accompanied by a striking increase in the Treg/Teff ratio in the T cells in lymphoid organs and atherosclerotic lesions.