RIMS4 codes for a presynaptic protein that plays a key role in dendritic and axonal morphogenesis.27RIMS1 and RIMS3 have already been associated with autism.28 The individual (PN400137) carrying the de novo RIMS4 stop variant (p.Y204*; CADD = 38) has a normal IQ (Performance IQ = 108, Verbal IQ = 116). The gene discussed is RIMS3; the disease is autism.