Indeed, BAG3 and HSPB8 whose expression was upregulated specifically in astrocytes in the PD brain [11], have been shown to be able to promote autophagy, indicating that alterd autophagy process in astrocytes is involved in the failure of glial inclusion clearance in PD and may thus contribute to disease onset/progression in neurodegeneration. This evidence concerns the gene BAG3 and Parkinson disease.