Due to the taxonomic microbiome, composition was different between two HCC groups, 11 significantly discriminative pathways (biosynthesis of 12, 14 and 16 membered macrolides, mRNA surveillance pathway, indole alkaloid biosynthesis, p53 signaling pathway, small cell lung cancer, toxoplasmosis, betalain biosynthesis, influenza A, viral myocarditis, colorectal cancer, cytochrome P450) between NBNC-HCC and B-HCC patients. This evidence concerns the gene TP53 and hepatocellular carcinoma.