TGFB1 and neoplasm: In a different novel suicide gene approach that increases radioiodine uptake in tumors, Schug et al. [152] stably transfected hBMSCs with sleeping beauty transposon encoding for sodium iodide symporter (NIS) driven by a TGFβ-1-responsive promoter, to induce expression of NIS when hBMSCs are within tumor stroma that secretes TGFβ-1.