In particular, fetuin-A concentrations were increased in the MA group compared to the MH group in subjects without obesity (717.1 [632.1, 769.7] vs. 599.5 [502.0, 709.3], P = 0.001) and with obesity (704.1 [595.5-880.9] vs. 612.2 [547.9-802.1], P = 0.016) (Figure 1). This evidence concerns the gene AHSG and obesity due to melanocortin 4 receptor deficiency.