Moreover, after multiple adjustments for diverse confounding factors, the ORs were 12.75 (95% CIs = 1.62-100.49; P for trend = 0.017) and 3.77 (95% CIs = 1.13-12.60; P for trend = 0.028) for the highest tertiles of fetuin-A compared to the lowest tertiles in groups without and with obesity, respectively. Here, AHSG is linked to obesity due to melanocortin 4 receptor deficiency.