In this study, we compared the levels of CASC2 in the pancreatic cancer cell lines CAPAN-1, BxPC-3, JF305, PANC-1 and SW1990 and in normal pancreatic HPDE6-C7 cells and analyzed the mechanism of the CASC2-regulated metastasis of PANC-1 cells. This evidence concerns the gene CASC2 and familial pancreatic carcinoma.