MAPK3 and systemic sclerosis: The formula targets mainly participate in the SSc pathological process of inflammation and vascular dysfunction: positive regulation of ERK1 and ERK2 cascade, positive regulation of neutrophil chemotaxis, NF-kappaB import into nucleus, positive regulation of MAP kinase activity, positive regulation of angiogenesis, regulation of prostaglandin secretion while the disease genes mainly involve in the immunity alterations: regulation of regulatory T cell differentiation, regulation of tyrosine phosphorylation of Stat4 protein, activation of JAK2 kinase activity.