For instance, the targets Interleukin-6 (IL-6) and matrix metalloproteinases1 (MMP1) shared by 4 compounds can be regarded as the therapeutic targets in systemic sclerosis (SSc), the former induce chronic inflammation, endothelial abnormality and fibroblast activation which are crucial to SSc while the latter involves in the process of tissue remodeling, increasing the risk of idiopathic pulmonary fibrosis34–36. This evidence concerns the gene MMP1 and systemic sclerosis.