HIF1A and scleroderma: Functional analysis of GFW targets suggested that the therapeutic effect of GFW decoction may be caused by the regulation of HIF-1 signaling pathway, vascular smooth muscle contraction, Toll-like receptor signaling pathway, Biosynthesis of antibiotics, which are related to the characteristic manifestations of scleroderma: tissue fibrosis, microvascular damage, activation of the immune system.