CD8A and neoplasm: Possible explanations for the low level of CD8+ TIL despite high predicted neoepitope load might be inefficient T-cell priming, immunodominance of some neoepitopes, deficient T-cell repertoire of patients, or low/lack of neoepitope presentation on the tumour cells due to defects in expression of some antigen processing and presenting machinery (APM) components.