With the exception of OS03, OS04, BZ16 and BZ35 tumours that had the highest CD8A gene expression and no downregulation of expression of the analysed APM components, all the other OS tumours had downregulation of expression of the analysed APM components that most likely interfere with neoepitope processing and presentation by tumour cells (Figs 4c and 5c, Supplementary Figs S3 and S5). The gene discussed is ANPEP; the disease is neoplasm.