CDK4 and glioblastoma: It has been suggested that AGAP2 overexpression is, in some cases, linked to the amplification of the CDK4 amplicon that occurs in several cancers14: AGAP2 gene is located in chromosome 12 adjunct to the CDK4 gene and, recently, it has been established that AGAP2 and CDK4 increased co-expression drives glioblastoma progression15.