ABCC2 and acute lymphoblastic leukemia: MRP2 overexpression is associated with relapse in AML patients (n = 30)18 and with lower 2-year survival in acute leukemias (n = 71)10 with reduced RFS in ALL patients (n = 105)26, as well as with poor response to chemotherapy comprising of 5-flurouracil, doxorubicin and cisplatin in esophageal squamous cell carcinoma13.