In addition, expression of the centroblast, GCB-centroblast, and GCB vincristine resistant subtype of DLBCL was significantly downregulated compared to healthy lymph nodes (p = 0.004, p = 0.001, p = 0.0004, respectively, Fig. 6B–D), contradictory to the higher NOTCH3 gene expression observed in DLBCL BAGS subtypes compared to healthy B-cell subsets from tonsils at Supplementary Fig. 4A,B. Here, NOTCH3 is linked to diffuse large B-cell lymphoma.