NOTCH3 −exon 16 transcript expression was able to differentiate DLBCL into molecular subtypes, however, when comparing the expression in healthy lymph nodes (n = 6) to the entire DLBCL cohort, the NOTCH3 −exon 16 transcript failed to discriminate DLBCL from healthy controls (Fig. 6A). Here, NOTCH3 is linked to diffuse large B-cell lymphoma.