Implication of NOTCH3 in chemoresistance have been reported in breast and ovarian cancer35–37, however, to our knowledge, the role of the NOTCH3 −exon 16 transcript in vincristine response has not been described previously, yet current data support that NOTCH3 −exon 16 splice events have an effect on the vincristine resistance mechanism in DLBCL. Here, NOTCH3 is linked to diffuse large B-cell lymphoma.