In women aged <45 years, nonvisceral obesity decreased the risk of RLD (odds ratio [OR], 0.67; 95% confidence interval [CI], 0.56–0.80), even after adjustment for the confounding factors WHtR and MAP (OR, 0.77; 95% CI, 0.61–0.96), and it remained significant after further adjustment with FPG and CRP (OR, 0.76; 95% CI, 0.60–0.94). This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.