It is compelling to consider that expanded T cell clonotypes from HAM/TSP patients may be specific for HTLV-I proteins such as HTLV-I tax, since it is known that in HLA-A*0201 HAM/TSP patients, the frequency of Tax specific CD8+ T-cells is extraordinarily high in peripheral blood and even higher in CSF39,40. The gene discussed is CNTN2; the disease is tropical spastic paraparesis.