BRCA1 and breast cancer: To determine if tumors from these two new mouse models reflected the basal-like subtype typical for human BRCA1-deficient breast cancer, we performed RNA-sequencing on 22 WB1P tumors and 7 tumors from B1P mice injected with Lenti-Cre, and compared their expression profile to tumors from the KB1P mouse model and a mouse model of luminal breast cancer (WapCre;Cdh1F/F;PtenF/F, WEP; 25), using a three-gene signature that distinguishes the PAM50 subtypes26.