In both groups injected with ISL1 knockdown cells (five mice per group), tumor growth was evidently slower, and the resulting tumors were smaller; moreover, two in the SGC7901-shRNA1# group and three mice in the SGC7901-shRNA2# group failed to grow tumors; one mice in the MGC803-shRNA1# and shRNA2# group failed to grow tumors. Here, ISL1 is linked to neoplasm.