GLS and ovarian carcinoma: Increased GLS1 mRNA expression was also associated with decreased survival in 1656 ovarian cancer patients (p = 0.0076) (Fig. 1g), and NCBI Gene Expression Omnibus data (http://www.ncbi.nlm.nih.gov/geo/) for 986 cases of colorectal cancer (p = 0.0017) (Fig. 1h).