It could directly affect ovarian theca cells and decreased FSH-stimulated 3β-HSD, StAR, CYP11A1 and aromatase activities in both rat granulosa cells and women with PCOS, with reduction of basal and of FSH-stimulated progesterone and estradiol levels as a consequence [53]. The gene discussed is BRD2; the disease is polycystic ovary syndrome.