Consistently, single drug treatment resulted in fewer formed colonies (Figure 1E,F), and the combination drugs imposed the most severe growth inhibition on the tested cells, suggesting that ABT263 + AXIT in combination may be a potent inhibitor for the growth of KRAS-mutant colon cancer cells (P < 0.001, Figure 1G,H). The gene discussed is KRAS; the disease is malignant colon neoplasm.