In the present study, we employ the combinatorial drugs targeting KRAS synthetic lethal genes in colon cancer cells; we found that ABT263 (a Bcl-xL inhibitor) and axitinib (AXIT), a tyrosine kinase inhibitor selective for vascular endothelial growth factor receptors [(VEGFR)-1, -2, and -3], showed cytotoxic effects. Here, KRAS is linked to malignant colon neoplasm.