Everything included, we have then demonstrated that MG dicarbonyl stress endows breast cancer cells with genetic changes, notably affecting (i) ECM matrix reorganization, (ii) MEK/ERK cascade via cross-talk with SMAD1 transcriptional activity and (iii) DUSPs inhibition, which ultimately promoted their migratory and metastatic potential (Fig. 7i). Here, SMAD1 is linked to breast carcinoma.