TNC and cancer: Comprehensive RNA-sequencing (RNASeq) analysis of GLO1-depleted cancer cells identified a metastatic transcriptomic signature involving genes tightly associated with cell migration and extracellular matrix (ECM) remodeling, such as collagens and tenascin C. We have demonstrated that MG-induced pro-metastatic signature is linked with the activation of the mitogen-activated protein kinase kinase (MEK)/extracellular signal-related protein kinase (ERK) pathway, which signals through activated SMAD1.