As increased inflammation is a common feature of tauopathies [2, 11, 12, 14, 18, 25] and was previously observed in TauP301L-AAV mice at 6 months of age [8], we evaluated GFAP and IBA1 levels, which revealed that both markers are already significantly elevated in TauP301L-AAV animals by 3 months of age. This evidence concerns the gene AIF1 and tauopathy.