AKT1 and neoplasm: The activated EGFR stimulates various downstream signaling pathways, including the Ras/Mitogen-activated protein kinase kinase kinase (Raf, MAP3K)/Mitogen-activated protein kinase kinase (MEK, MAP2K)/ Mitogen activated protein kinase (MAPK), Phosphoinositide 3-kinase (PI3K)-Protein kinase B (AKT) and the Janus Kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathways, leading to tumor development and metastasis [8, 9].