Paclitaxel is a mitotic blocker by stabilizing microtubules, and parkin overexpression induced by Mito treatment can promote the binding of parkin to microtubules, resulting in a synergistic enhancement of Paclitaxel-induced microtubule assembly and stabilization to accelerate mitotic block and apoptosis in breast cancer [48]. Here, PRKN is linked to breast carcinoma.