In the present study, we also compared protein markers alteration in T2DM_CAD groups with CAD group, metabolic hormones i.e., insulin, GIP and GLP-1 levels were significantly (fdr corrected p-value < 0.10) increased where IP-10 levels were decreased in T2DM_CAD as compared with CAD group. The gene discussed is INS; the disease is coronary artery disorder.