With the help of the network analysis, we were able to identify several cellular network proteins like PTPN1, AKT1, INSR, LEPR, IRS1, IRS2, AKT1, IL1R2, IL6R, PCSK9 and MYD88, which are responsible for regulating inflammation, insulin resistance, and atherosclerosis. Here, IRS1 is linked to atherosclerosis.