Network meta-analysis showed Fluvastatin (97.7%), Atorvastatin and Rosuvastatin had higher overall probability, and they were more effective in reducing CRP than other statins in COPD patients; Simvastatin, Rosuvastatin and Pravastatin had higher overall probability, and they were more effective in reducing IL-6 than other statins in COPD patients. This evidence concerns the gene CRP and chronic obstructive pulmonary disease.