Given that the number and location of NF1-related aneurysms are different from non-NF1-related aneurysms [30] and that NF1 aneurysms can be caused without hypertension [31], the primary etiologies of the LCA aneurysms may be the weakness of vessel wall inherent to NF1. Here, NF1 is linked to Leber congenital amaurosis.