Goyal et al. also observed significant increases is SOD in POAG (46.19 ± 6.79 U/mL), and primary angle-closure glaucoma (PACG; 44.38 ± 6.47 U/mL) compared to cataract controls (21.70 ± 4.93 U/mL; p<0.0001) (222). Here, SOD1 is linked to glaucoma.