In addition to these extracellular proteins, several intracellular proteins such as Annexin A1 (ANXA1), Annexin A11 (ANXA11), aldehyde hydrogenase 3A1, clusterin, Glutathione-S-transferase P1, have also been shown to be deregulated in tears of dry eye patients (78,83,85). This evidence concerns the gene ANXA1 and dry eye syndrome.