Interleukin-8 (IL-8), also called as chemokine (C-X-C motif) ligand 8 (CXCL8), a key cytokine that directs the migration of neutrophils, basophils and T-lymphocytes by mediating innate immune and angiogenic response, has consistently been reported to be elevated in tears of dry eye patients (42,58,63,72,73). The gene discussed is CXCL8; the disease is Keratoconjunctivitis sicca.