They also identified 6 proteins that were upregulated in tears from dry eye patients which include α-enolase, α-1-acid glycoprotein1 (AGP), S100A8/Calgranulin A, S100A9/Calgranulin B, S100A4 and S100A11 (Calgizzarin). This evidence concerns the gene S100A8 and Keratoconjunctivitis sicca.