TTR and early-onset autosomal dominant Alzheimer disease: Inoue et al. has shown that proteins such as apolipoprotein (APO) AI, APO CIII, APO E, transthyretin (TTR), α2-macroglobulin and Cystatin-C, which are known to be elevated in Alzheimer’s disease, are also increased in the AH of POAG patients (179).