The univariate regression analysis showed that LDLR promoter methylation was significantly associated to the presence of CHD (OR = 0.464 CI 95% = 1.049–1.480; p = 0.043) while LDLR, SREBF2 and ABCA1 gene expression were predictors of both CHD and critical stenosis (OR = 1.516 CI95% = 1.024–2.245, p = 0.038; OR = 1.281 CI 95% = 1.049–1.588, p = 0.024; OR = 1.249 CI95% = 1.034–1.480, p = 0.012; respectively) (Table 3). The gene discussed is SREBF2; the disease is coronary artery disorder.