LDLR and coronary stenosis: Gene expression data demonstrated an up-regulation of LDLR (p = 0.007), SREBF2 (p = 0.003) and ABCA1 (p = 0.004) in CHD patients with stenosis degree ≥50% vs HS, with a significance for SREBF2 mRNA overexpression in the group with coronary stenosis ≥50% as compared to <50% (p = 0.036) (Fig 3G, 3H and 3I and Table 2).