Results from statistical analysis derived from the NCPV and the molecular data showed a differential methylation of LDLR promoter segment in CHD patients with NCPV>50 compared to HS (p = 0.005) but this epigenetic data was not able to discriminate patients with a prevalent non-calcified plaque composition (NCPV>50 vs NCPV<50 patients) (Fig 5D). The gene discussed is LDLR; the disease is coronary artery disorder.