MeDIP data showed an increased methylation in LDLR promoter of CHD patients with a TPV >100 (1.9%±0.44) compared to HS (p = 0.001) with a significant difference between TPV >100 and TPV <100 (0.92%±0.26; p = 0.021) groups (Fig 5G). This evidence concerns the gene LDLR and coronary artery disorder.