In addition, gene expression analysis showed a significant up-regulation of LDLR (p = 0.021), SREBF2 (p = 0.019) and ABCA1 (p = 0.008) mRNA levels in CHD patients as compared to HS (Fig 3A, 3B and 3C and Table 2). This evidence concerns the gene ABCA1 and coronary artery disorder.