In particular, the percentage of methylation at the analyzed locus in LDLR promoter was high in CHD patients with PB>50% (1.60%±0.51; p = 0.024) compared to HS and in PB<50% patients (1.28%±0.29; p = 0.042) compared to HS. This evidence concerns the gene LDLR and coronary artery disorder.