These results support the hypothesis that galectin-3 is secreted by activated macrophages and mediates profibrotic processes in myocarditis-induced heart failure.[5, 19, 21] Furthermore, our results revealed that infiltration of galectin-3 positive cells and myocardial fibrosis started as early as 48 hours after virus inoculation and was completed by 7 days. Here, LGALS3 is linked to heart failure.