To further evaluate the rhGH-mediated effect on cell proliferation and angiogenesis in MKN-45 xenograft tumors, we conducted IHC to detect the expression of the cell proliferation marker Ki-67 and angiogenes is markers VEGF and CD31 in MKN-45 tumor xenograft tumors (Fig 2B). This evidence concerns the gene PECAM1 and neoplasm.