As shown in Fig 2C, the expression levels of Ki-67, VEGF and CD31 showed no significant difference between the rhGH high-dosage group or rhGH middle-dosage group and control group but were decreased in the rhGH low-dosage group, a finding in accordance with the rhGH-mediated effect on MKN-45 xenograft tumor growth. This evidence concerns the gene PECAM1 and neoplasm.