In the multivariate logistic regression analysis to adjust the baseline differences for age, male gender, patient origin from ER, SOFA score, and sepsis (Table 1), decreased TIBC and transferrin upon ICU admission remained highly associated with RBC transfusion within 28 days of ICU admission (P < 0.001; Table 2) (ROC curve; S1 Fig). This evidence concerns the gene TF and Sepsis.