Compared with the reference group, subjects in the incident NAFLD group were more likely to be men, to have smoked, and to drink alcohol, and had higher blood pressure, and higher levels of fasting glucose, total cholesterol, triglycerides, LDL-C, hepatic enzymes, insulin, HOMA-IR, and hsCRP and lower levels of HDL-C (Table 1). The gene discussed is INS; the disease is metabolic dysfunction-associated steatotic liver disease.