Vesicular trafficking is supported by F-actin.,and STX1A and VAMP2 were shown to interact with F-actin for SNARE-dependentexocytosis (Daniel et al.,2002; Nevins and Thurmond, 2005).Enhanced expression of STX1A and VAMP2, as shownhere in bladder cancer and in previous studies in other cancers (Grabowski et al., 2002; Steffen et al., 2008; Meng and Wang, 2015) suggest their involvementin abnormal vesicular trafficking that might have a critical role in tumor formationand metastasis. This evidence concerns the gene VAMP2 and neoplasm.