In contrast, both CPSF6 knock-down and the N74D exchange impaired HIV-1 infection in post-mitotic primary human macrophages (Schaller et al., 2011; Ambrose et al., 2012), and this effect was attributed to induction of an interferon response triggered by viral DNA sensing (Rasaiyaah et al., 2013). This evidence concerns the gene CPSF6 and HIV-1 infection.