The TMEM16E protein (synonymous to anoctamin 5) has been attracting a great deal of interest, since mutations in the human TMEM16E gene were implicated in two different types of hereditary diseases: in gnathodiaphyseal dysplasia (GDD), a rare skeletal syndrome [1], and in muscular dystrophies, limb-girdle muscular dystrophy-2L (LGMD2L) and distal Miyoshi myopathy (MMD3) [2]. The gene discussed is ANO5; the disease is muscular dystrophy.